Technically speaking, as long as you are the registered owner of the domain and can modify DNS MX records to point to our mail servers then we can filter your mail. However, to be effective our mail servers must be listed exclusively in the DNS MX records for your domain. This is not an issue for most "Dedicated" or "Virtual Dedicated" hosting plans and is obviously not a problem if you run your own email servers.
However, many hosts that specialize in "economy-priced" shared hosting plans provide very limited technical capability. The inbound email servers at these types of operations often do not actually know what domains they are hosting. In these cases, if the host's mail server doesn't "see itself" listed in the MX records it will incorrectly assume that it is not hosting your email and will then reject your inbound emails after we've filtered them. Examples of hosts with this type of simplistic management include the "shared hosting" plans at SBC Global, 1&1, XO and NoMonthlyFees.com, among others.
You can tell whether this will be a potential issue by reviewing your own MX records. If you find your domain listed then you can be confident that we can filter and deliver your email. On the other hand, if your MX records only reference your host's domains, then you should contact your host to verify whether or not their system will support outside MX filtering services.
Even if your host lacks much sophistication, there are still several solutions for working around their limitations:
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You can host your email with our "Robust, No-Frills Email Hosting Service" so that we both filter and host your email. This is independent of web site hosting, which we do not offer.
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The better hosts (Pair.com being an example) can configure their servers to accept email for your domain, even when their servers are not listed in the DNS MX records. A simple request to your host's Support department is all that should be required.
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You may need to upgrade to a "Dedicated" or "Virtual Dedicated" plan with your host before they'll allow you to manage your own MX records.
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You could have the host register DNS "A" records for "yourdomain.yourhost.tld"
Replace your existing MX entries with the new server name above, and
Create a "CNAME" records for the above that point to our mail filtering systems 
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Alternatively, you could simply leave one of the host's email servers listed in the DNS MX but also:
Assign the host's mail-server the "highest numeric value" preference number allowed, and
Have the host restrict the mail-server (if they're capable) so that it will only accept messages for your domain when the connection is from our outbound servers.
Whether we host your email or you apply the above work-around solutions, as long as your host will accept your mail, then OnlyMyEmail can provide you with award-winning, world-class spam filtering.
Keep in mind, however, that hosts with mail-servers that rely on the DNS system to tell them who their clients are will very often lack the technical competence to understand and/or implement changes to their own email servers. Others may intentionally prevent you from using outside email filtering solutions in order to sell you add-on filtering they offer themselves.
